although mastectomy in some form is still the response to breast cancer chosen by many surgeons, it is important to know that it is not the only possible treatment. hormone therapystudies involving postmenopausal women who were given the hormone tamoxifen in conjunction with surgery also reported a significant survival advantage according to the national cancer institute. as a matter of fact, it may actually offer some protection against bone loss.while tamoxifen acts against the effects of estrogen in the breast tissue, it acts like estrogen in other systems of the body, according to cancer facts published by the national cancer institute (nci).
with the in-depth analysis of a study, reported in 1992, experts believe tamoxifen therapy with or without chemotherapy, may also be indicated in women in whom cancer is caught in the early stage.doctors may prescribe chemotherapy, hormonal therapy, or a combination of the two. this, coupled with insights from clinical studies that ate on-going should, in time, help eliminate the uncertainty of women facing breast cancer treatment.discuss these alternative treatments with your surgeon and/or family physician. rather, she should discuss the alternatives with her doctor(s).breast cancer specialists stress that for most patients, the decision of whether or not to have mastectomy should be strictly a matter of personal choice.
in this review, we discussed some significant natural chemical compounds with their mechanisms of actions, which can be very effective against the breast cancer and can be more potent by their proper modifications and further clinical research. the etiology of breast cancer and proliferation of cancerous cells is generally mediated by a number of mechanisms or pathways [13–16]. the development of targeted therapy in tnbc is very challenging, though lehmann et al. from many studies, it is evidenced that many of the natural compounds have anticancer activity and they have the property to function as a treatment approach via many mechanisms (figure 2) [45–48]. found a positive correlation between the expression levels of cox-2 and distant metastases in breast cancer . in combination therapy with herceptin, dim reduced the expression of foxm1 in her-2/neu-expressing breast cancer cells through downregulating akt and nf-kb p65 . it was reported that biochanin a is tolerated better than genistein and causes positive expression of tumor suppressor genes in hmec, mcf 12a, and mcf7 (er-positive breast cancer cell line) cell lines [91, 178]. curcumin is reported to induce breast cancer apoptosis by regulating the expression of apoptosis related genes and proteins . it can be suggested that curcumin is one of the most significant compound to face the challenges of breast cancer treatment.  suggested that egcg inhibited the proliferation of estrogen-sensitive mcf-7 breast cancer cell line and also binds to both erα and erβ .
it is also reported that genistein induced apoptosis via the upregulation of bax and p21waf1 proteins in mda-mb-231 cell lines  and also downregulated the expression of caspase-3 . the expressions of other genes such as rarβ2 and hin1 remained unaltered by lycopene treatment in mcf-7 and mda-mb-468 breast cancer cells [131, 213]. in er-positive breast cancer cell, shikonin induces apoptosis with the characteristics of necroptosis  and also decreases the expressions of steroid sulfatase genes . at the same time it can induce cell cycle arrest and apoptosis in breast cancer cells. reported that resveratrol acts as dnmt 3b inhibitor and decreases in rassf-1α methylation with increasing circulating resveratrol and it also suppresses expression of the androgen receptor . showed that , in the presence of e2, resveratrol acts as antiestrogen and an agonist or antagonist in the absence of e2 in different breast cancer cell lines. in adjuvant therapy, silibinin is reported to increase the efficacy of cisplatin and paclitaxel in mcf-7 breast cancer cells  and also to sensitize the chemoresistant breast cancer cells . a natural compound egcg, derived from green tea, is reported to block uncontrolled cell growth and can inhibit the migratory behavior of triple-negative breast cancer . the significance and contribution of natural derived compounds in the treatment and prevention of breast cancer is evident and cannot be ignored. molecular targets of natural compounds in breast cancer pathway.
as a matter of fact, it may actually offer some protection against bone loss. while tamoxifen acts against the effects of estrogen in the breast tissue, it acts rosemary extract can increase activity of anti-breast-cancer agent tamoxifen, trastuzumab, and paclitaxel . these can be great fields for future research some doctors would now start with arimidex or the others instead of tamoxifen. others show data suggesting that a prudent approach is to switch, natural alternatives to tamoxifen, natural alternatives to tamoxifen, tamoxifen alternatives 2021, tamoxifen alternatives 2020, tamoxifen side effects.
ais, tamoxifen, and fulvestrant can be used to treat more advanced hormone-positive breast cancers, especially in post-menopausal women. they try a mediterranean diet. the mediterranean dietary pattern is associated with a decreased risk of breast cancer. to follow a mediterranean diet, you need to tamoxifen, known by the brand names nolvadex and soltamox, is a commonly prescribed prescription drug used to treat hormone receptor-positive, choosing not to take tamoxifen, estrogen blockers for females. arimidex still better than tamoxifen after surgery to reducearimidex (chemical name: anastrozole)aromasin (chemical name: exemestane)femara (chemical name: letrozole)
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