for the past three decades the use of tamoxifen has been one of the few relatively easy decisions for most postmenopausal women after surgery or other treatment for breast cancer. it is used to treat women with metastatic breast cancer — disease that has spread — or to reduce the risk of recurrence after treatment for early stage breast cancer. now with the introduction of aromatase inhibitors, a newer class of anti-estrogens, the picture has changed dramatically, and women and their oncologists have choices. the risk of endometrial cancer in women taking tamoxifen was small but real. this and other studies are accumulating to show that the aromatase inhibitors are safer than tamoxifen and outdo it in prevention of recurrence or disease in the other breast.
what’s more, one of the aromatase inhibitors, a drug called femara, or letrozole, has been shown to take over after five years of tamoxifen and keep the benefit going. what is becoming more and more evident, according to a report by the american society of clinical oncology (asco), a major u.s. group of cancer doctors, is that aromatase inhibitors belong somewhere in the first five years after primary therapy for breast cancer. proponents for arimidex believe the study of 9,366 women with localized breast cancer amounted to strong evidence that the best idea for many is to start with the aromatase inhibitor, foregoing tamoxifen entirely. the aromatase inhibitor also prevented some of the side effects, albeit rare, of tamoxifen. in the arimidex study, women taking the aromatase inhibitor had significantly fewer cases of endometrial than women taking tamoxifen.
the american cancer society offers programs and services to help you during and after cancer treatment. hormone therapy is often used after surgery (as adjuvant therapy) to help reduce the risk of the cancer coming back. hormone therapy can also be used to treat cancer that has come back after treatment or that has spread to other parts of the body. because estrogen stimulates hormone receptor-positive breast cancers to grow, lowering the estrogen level can help slow the cancer’s growth or help prevent it from coming back. ovarian suppression along with tamoxifen or an ai might be recommended for women whose breast cancer is at high risk of coming back. after surgery, hormone therapy can be given to reduce the risk of the cancer coming back. adjuvant endocrine therapy for women with hormone receptor-positive breast cancer: american society of clinical oncology clinical practice guideline update on ovarian suppression.
long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6,953 women with early breast cancer. treatment approach to metastatic hormone receptor-positive, her2-negative breast cancer: endocrine therapy and targeted agents. diseases of the breast. adjuvant endocrine therapy for women with hormone receptor-positive breast cancer: american society of clinical oncology clinical practice guideline update on ovarian suppression. long-term effects of continuing adjuvant tamoxifen to 10 years versus stopping at 5 years in 6,953 women with early breast cancer. treatment approach to metastatic hormone receptor-positive, her2-negative breast cancer: endocrine therapy and targeted agents. diseases of the breast. diseases of the breast.
with the in-depth analysis of a study, reported in 1992, experts believe tamoxifen therapy with or without chemotherapy, may also be indicated in women in whom tamoxifen doesn’t work for everyone. evista, fareston, faslodex, arimidex, and femara are some tamoxifen alternatives. get the full list here. rosemary extract can increase activity of anti-breast-cancer agent tamoxifen, trastuzumab, and paclitaxel [248]. these can be great fields for future research, natural alternatives to tamoxifen, natural alternatives to tamoxifen, tamoxifen alternatives 2021, tamoxifen alternatives 2020, tamoxifen side effects.
arimidex (chemical name: anastrozole) aromasin (chemical name: exemestane) femara (chemical name: letrozole) some doctors would now start with arimidex or the others instead of tamoxifen. others show data suggesting that a prudent approach is to switch ais, tamoxifen, and fulvestrant can be used to treat more advanced hormone-positive breast cancers, especially in post-menopausal women. they all drugs have risks and side effects that must be discussed when making the decision about chemoprevention. most experts agree that tamoxifen, natural alternatives to hormone therapy for breast cancer, choosing not to take tamoxifen.
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