in this review, we discussed some significant natural chemical compounds with their mechanisms of actions, which can be very effective against the breast cancer and can be more potent by their proper modifications and further clinical research. the etiology of breast cancer and proliferation of cancerous cells is generally mediated by a number of mechanisms or pathways [13–16]. the development of targeted therapy in tnbc is very challenging, though lehmann et al. from many studies, it is evidenced that many of the natural compounds have anticancer activity and they have the property to function as a treatment approach via many mechanisms (figure 2) [45–48]. found a positive correlation between the expression levels of cox-2 and distant metastases in breast cancer . in combination therapy with herceptin, dim reduced the expression of foxm1 in her-2/neu-expressing breast cancer cells through downregulating akt and nf-kb p65 . it was reported that biochanin a is tolerated better than genistein and causes positive expression of tumor suppressor genes in hmec, mcf 12a, and mcf7 (er-positive breast cancer cell line) cell lines [91, 178]. curcumin is reported to induce breast cancer apoptosis by regulating the expression of apoptosis related genes and proteins . it can be suggested that curcumin is one of the most significant compound to face the challenges of breast cancer treatment.  suggested that egcg inhibited the proliferation of estrogen-sensitive mcf-7 breast cancer cell line and also binds to both erα and erβ .
it is also reported that genistein induced apoptosis via the upregulation of bax and p21waf1 proteins in mda-mb-231 cell lines  and also downregulated the expression of caspase-3 . the expressions of other genes such as rarβ2 and hin1 remained unaltered by lycopene treatment in mcf-7 and mda-mb-468 breast cancer cells [131, 213]. in er-positive breast cancer cell, shikonin induces apoptosis with the characteristics of necroptosis  and also decreases the expressions of steroid sulfatase genes . at the same time it can induce cell cycle arrest and apoptosis in breast cancer cells. reported that resveratrol acts as dnmt 3b inhibitor and decreases in rassf-1α methylation with increasing circulating resveratrol and it also suppresses expression of the androgen receptor . showed that , in the presence of e2, resveratrol acts as antiestrogen and an agonist or antagonist in the absence of e2 in different breast cancer cell lines. in adjuvant therapy, silibinin is reported to increase the efficacy of cisplatin and paclitaxel in mcf-7 breast cancer cells  and also to sensitize the chemoresistant breast cancer cells . a natural compound egcg, derived from green tea, is reported to block uncontrolled cell growth and can inhibit the migratory behavior of triple-negative breast cancer . the significance and contribution of natural derived compounds in the treatment and prevention of breast cancer is evident and cannot be ignored. molecular targets of natural compounds in breast cancer pathway.
if we are not careful, this imbalance in estrogen and testosterone levels in men will add up to the global burden. estrogen dominance in men happens when the balance between normal levels of testosterone and estrogen is lost. this is a cause and a consequence of estrogen dominance. according to studies, higher levels of estrogen cause a thickening of the carotid artery. all of this highlights the importance of maintaining a balance between estrogen and testosterone in men. it maintains a relatively low level of estrogen in a man’s body, which is good and protect us from the disease. it increases the circulating levels of estradiol and lowers testosterone levels.
as a result of these factors, we get an imbalance of testosterone to estradiol ratio. this is one of the most important herbs to balance a man’s hormonal system. it is very useful in patients with estrogen dominance and prostate problems (13). estro clear works as part of a healthy diet and lifestyle to help reduce excess estrogen for men with estrogen dominance or low testosterone levels. after reading all of the above, you may conclude that estrogen is your number one enemy. by maintaining a good proportion of testosterone and estradiol, we will be able to detect and treat estrogen dominance as soon as possible. 11420039) is registered in uk, manufactures in the us and distributes globally.
 and aromatase inhibitors by chumsri et al. . a number of phytochemicals such as curcumin, ginsetin, lycopene, and apigenin have been directly this is why body builders use aromatase inhibitors: more testosterone, less estrogen! used for post menopausal women who have er positive breast cancer: • alternative treatment options: what’s worked for me. i was prescribed an aromatase inhibitor, arimidex (anastrozole)., what is the strongest natural aromatase inhibitor, natural aromatase inhibitors herbs, natural aromatase inhibitors herbs, aromatase inhibitors natural foods, alternative to aromatase inhibitor.
one common strategy is the use of natural aromatase inhibitors, such as flavonoids. in particular, chrysin, naringin, naringenin, hesperetin, eriodictyol, and apigenin   are among the compounds shown to have significant inhibitory effects on aromatase. flaxseed meal and white button mushrooms both can be eaten as foods and both inhibit aromatase activity. melatonin and grape seed extract may be chrysin is a naturally occurring flavonoid from the passion flower plant and a strong natural ai with in vitro research supporting its effects. purpose aromatase inhibitor therapy (ai) significantly improves survival in breast cancer patients. little is known about adherence and, natural alternatives to anastrozole, which aromatase inhibitor is best with least side effects.
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