you can help reduce your risk of cancer by making healthy choices like eating right, staying active and not smoking. tamoxifen and raloxifene have been shown to reduce the risk of breast cancer in women with a higher-than-average risk, but these drugs can have their own risks and side effects. the effect of these drugs on breast cancer risk has varied in different studies. for example, if you had a 5% risk of getting breast cancer in the next 5 years, you would be considered at increased risk. in the major studies looking at these drugs for breast cancer prevention, the overall risk of these blood clots over 5 years of treatment was less than 1%. this risk could be higher if you had a serious blood clot in the past, so these drugs are generally not recommended to lower breast cancer risk for anyone with a history of blood clots.
tamoxifen for the prevention of breast cancer: current status of the national surgical adjuvant breast and bowel project p-1 study. 2001;286(18):2251-2256. nelson hd, fu r, zakher b, pappas m, mcdonagh m. medication use for the risk reduction of primary breast cancer in women: updated evidence report and systematic review for the us preventive services task force. effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the nsabp study of tamoxifen and raloxifene (star) p-2 trial. tamoxifen for the prevention of breast cancer: current status of the national surgical adjuvant breast and bowel project p-1 study. use of endocrine therapy for breast cancer risk reduction: asco clinical practice guideline update. effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the nsabp study of tamoxifen and raloxifene (star) p-2 trial.
estrogen and progesterone also promote the growth of some breast cancers, which are called hormone-sensitive (or hormone-dependent) breast cancers. hormone therapy for breast cancer should not be confused with menopausal hormone therapy (mht)—treatment with estrogen alone or in combination with progesterone to help relieve symptoms of menopause. blocking estrogen’s effects: several types of drugs interfere with estrogen’s ability to stimulate the growth of breast cancer cells: adjuvant therapy for early-stage breast cancer: tamoxifen is fda approved for adjuvant hormone treatment of premenopausal and postmenopausal women (and men) with er-positive early-stage breast cancer, and the aromatase inhibitors anastrozole, letrozole, and exemestane are approved for this use in postmenopausal women. both of these drugs and the aromatase inhibitor exemestane are also approved to treat postmenopausal women with advanced breast cancer whose disease has worsened after treatment with tamoxifen (14). hormone therapy is sometimes used for the neoadjuvant treatment of hr-positive breast cancer in postmenopausal women who cannot tolerate chemotherapy or when surgery needs to be delayed. both exemestane and anastrozole are approved by the fda for treatment of women with er-positive breast cancer.
relevance of breast cancer hormone receptors and other factors to the efficacy of adjuvant tamoxifen: patient-level meta-analysis of randomised trials. aromatase inhibitors versus tamoxifen in early breast cancer: patient-level meta-analysis of the randomised trials. phase iii study of letrozole versus tamoxifen as first-line therapy of advanced breast cancer in postmenopausal women: analysis of survival and update of efficacy from the international letrozole breast cancer group. ribociclib plus endocrine therapy for premenopausal women with hormone-receptor-positive, advanced breast cancer (monaleesa-7): a randomised phase 3 trial. effects of tamoxifen vs raloxifene on the risk of developing invasive breast cancer and other disease outcomes: the nsabp study of tamoxifen and raloxifene (star) p–2 trial. tamoxifen for prevention of breast cancer: extended long-term follow-up of the ibis-i breast cancer prevention trial. in the case of permitted digital reproduction, please credit the national cancer institute as the source and link to the original nci product using the original product’s title; e.g., “hormone therapy for breast cancer was originally published by the national cancer institute.”
most experts agree that tamoxifen and raloxifene should not be used to reduce breast cancer risk in women who: have a higher risk of serious tamoxifen and raloxifene are the only drugs approved in the us to help lower the risk of breast cancer, although for some women, two serms, tamoxifen and toremifene, are approved to treat metastatic breast cancer. the antiestrogen fulvestrant is approved for postmenopausal, .
tamoxifen, a synthetic hormone, blocks the action of the female hormone estrogen. it was once thought that tamoxifen sped up bone loss in postmenopausal women compare tamoxifen alternatives treatment for hormone receptor-positive early breast cancer in postmenopausal women adjuvant treatment of adjuvant hormone therapy for breast cancer: alternatives to tamoxifen. prescrire int. 2005 jun;14(77):108-10. pmid: 15984106, . arimidex still better than tamoxifen after surgery to reducearimidex (chemical name: anastrozole)aromasin (chemical name: exemestane)femara (chemical name: letrozole)
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